Nicotinic Acetylcholine Receptors and Cardiac Vagal activity in Rats with Type 2 Diabetes
نویسندگان
چکیده
Cardiovascular autonomic dysfunction is a common complication of the patients with type 2 diabetes mellitus (T2DM) [1-5], which is associated with a higher risk of sudden cardiac death in T2DM patients [1,4,6]. Unlike type 1 diabetes mellitus, the mechanisms responsible for the cardiovascular autonomic dysfunction have not been explored in T2DM even though T2DM affects 90 to 95% of the diabetic population worldwide [7] compared to 5 to 10% affected by type 1 diabetes mellitus. Data from one research group demonstrated that function of the parasympathetic nervous system is severely affected in T2DM patients [2].
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